Evaluation of the Antihyperlipidemic Potential of Ruellia tuberosa Root Extract

Abstract

The Ruellia tuberosa L. have both Chronic hyperlipidemia was induced by feeding female rats with High Fat Diet for 30 days. Acute hyperlipidemia was induced by administration of Triton X-100 (100mg/kg, i.p., at once) in female rats. Administration of Ruellia tuberosa Ethanolic extract (RTEE) (250/500/1000mg/kg) for 30 days in High Fat Diet (HFD) model and RTEE (250/500/1000mg/kg) for 7 days in triton models respectively, successfully prevented the elevation of serum triglycerides(TG), total cholesterol(TC),Low density lipoproteins(LDL), Very Low density lipoproteins (VLDL), Serum glutamate oxalo transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT),Alkaline Phosphatase and decrease of serum High density lipoproteins(HDL) in High Fat Diet (HFD) and Triton X-100 model rats in a dose dependent manner. The study find out that RTEE is a potent antihypercholesterolemic drug lowering the LDL, VLDL and increasing HDL levels in two hyperlipidemic models such as HFD, Triton X-100. The mechanism of action of this compound inhibits the cholesterol and triglyceride synthesis in animal models.