Evaluation of Antacid Activity of Ethanol and Aqueous Extracts of Carica papaya Leaves Using the Rosette-Rice Method

Abstract

The purpose of the present investigation is to rule out the antacid activity of Carica papaya leaves by invitro Rosette rice method . The reason for selecting invitro method was to minimize the usage of experimental animals. In this method sodium bicarbonate used as standard drug , water and ethanol as control. The preliminary chemical test performed for the extract showed the presence of alkaoids, glycoside, flavonoids, saponins. Then they are evaluated for the antacid potency by Rosette rice time( the time during which the pH is maintained between 3-5 ). It was observed that aqueous extract of carica papaya leaves showed higher antacid activity than ethanolic extract.